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This metabolite includes a PDE selectivity profile comparable to sildenafil and an in vitro potency for PDE5 approximately 50% on the guardian drug. Plasma concentrations of this metabolite are about forty% of All those noticed for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic results.

VIAGRA incorporates sildenafil, which is similar medication found in An additional drug known as REVATIO. REVATIO is employed to take care of a exceptional ailment known as pulmonary arterial hypertension (PAH).

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Speak to your Health care service provider to see When your coronary heart is robust sufficient for sexual intercourse. If you really feel chest ache, dizziness, or nausea throughout sexual intercourse, cease and call your Health care provider instantly.

VIAGRA was proven to potentiate the hypotensive results of nitrates and its administration in clients who use nitric oxide donors like organic nitrates or organic and natural nitrites in almost any form is consequently contraindicated [see CONTRAINDICATIONS, DRUG INTERACTIONS, and Medical PHARMACOLOGY].

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VIAGRA has systemic vasodilatory properties that resulted in transient decreases in supine hypertension in nutritious volunteers (signify utmost lower of 8.4/5.5 mmHg), [see Medical PHARMACOLOGY]. Although this Commonly would be predicted to become of little consequence in many people, before prescribing VIAGRA, medical professionals should cautiously contemplate no matter if their sufferers with underlying cardiovascular disease could possibly be impacted adversely by this sort of vasodilatory effects, especially together with sexual exercise.

Twenty topics gained VIAGRA fifty mg, but only 19 subjects obtained matching placebo. Just one affected person discontinued the analyze prematurely resulting from an adverse event of hypotension adhering to dosing with VIAGRA fifty mg. This affected person had been getting minoxidil, a powerful vasodilator, during the research.

Sildenafil is also available in an injectable variety that is frequently presented by a healthcare service provider inside of a healthcare facility or clinic.

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The concomitant administration in the protease inhibitor ritonavir considerably boosts serum concentrations of sildenafil (eleven-fold rise in AUC). If VIAGRA is prescribed to patients having ritonavir, warning must be utilised. Info from topics exposed to higher systemic amounts of sildenafil are minimal.

g., creatinine clearance < 30 mL/min), and concomitant usage of erythromycin or robust CYP3A4 inhibitors, plasma levels of sildenafil at 24 hours publish dose happen to be found for being 3 to 8 times greater than These noticed in wholesome volunteers. Even though more info plasma amounts of sildenafil at 24 several hours submit dose are much decreased than at peak concentration, it's not known whether or not nitrates is usually securely co-administered presently position [see CONTRAINDICATIONS].

Medical professionals need to inform clients not to take VIAGRA with other PDE5 inhibitors such as REVATIO or other pulmonary arterial hypertension (PAH) treatment plans containing sildenafil.

abnormal vision, including alterations in colour vision (such as aquiring a blue coloration tinge) and blurred eyesight